Toxicology > Rodent Toxicology

Toxicology studies in rodents and rabbits form the backbone of safety evaluation of both chemicals and pharmaceuticals. The Progenix Research facility includes an approximately 3200mē barriered rodent facility, housing rats, mice, guinea-pigs and rabbits for short to long term toxicity, carcinogenicity and reproductive toxicity studies.

A total of 40 animal rooms of various sizes ranging from rooms designed to house a single repeated dose toxicity study comprising 60 to 120 animals to rooms designed to hold life-time carcinogenicity studies in rats or mice and teratology studies in rabbits. The rodent vivarium includes integral necropsy rooms.

Study capability: Skin and eye irritation, skin sensitisation (local lymph node assay, Magnusson and Kligman [M&K], Buehler); acute oral toxicity, acute dermal toxicity, acute inhalation toxicity; single dose pharmaceutical studies; 14-day, 28-day, 3-month, 6-month and 1 year repeated dose toxicity studies; a full range of reproductive toxicity studies including pre-natal developmental toxicity in rats and rabbits, single- and multi-generation reproductive studies, carcinogenicity and combined chronic and carcinogenicity studies in mice and rats.

Routes of exposure: oral (gavage and dietary), intravenous (bolus to continuous infusion), intramuscular, subcutaneous, intradermal, intraperitoneal, inhalation, dermal and other specialised routes of exposure.
"...Toxicology studies in rodents and rabbits form the backbone of safety evaluation of both chemicals and pharmaceuticals"