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Progenix Research offers an extensive range of pre-clinical toxicity tests for chemical safety evaluation including tests for worldwide chemical notification, registration of plant protection products and biocides and studies for High Production Volume (HPV) programs under the Organisation for Economic Development and Co-Operation (OECD), Environmental Protection Agency (EPA) and International Congress & Convention Association (ICCA) schemes.
Irritancy
and sensitisation studies
Acute
toxicity
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Repeated dose
toxicity
28-day (sub-acute), 90-day (sub-chronic) and 1 year (chronic) toxicity
studies in rats and dogs by oral (gavage or dietary), dermal and inhalation
routes. OECD, EC, EPA, Japanese MAFF, Japanese Chemical Substance Control
Law, Food and Drug Administration (FDA) food additives etc. Full
neurotoxicity functional observation capability.
Neurotoxicity
Acute and repeated dose (28-day or 90-day) neurotoxicity studies according
to OECD, EPA and Japanese MAFF guidelines.
Carcinogenicity
Carcinogenicity and combined chronic and carcinogenicity studies in mice and
rats according to OECD, EC, EPA and JMAFF requirements. Oral, dermal or
inhalation exposure.
Reproductive
toxicology
Developmental toxicity in rats and rabbits, single- and multi-generation
reproductive studies to OECD, EC, EPA and Japanese MAFF guidelines.
Reproduction/developmental toxicity screening studies (OECD 421) and
combined repeated dose oral toxicity/reproductive developmental toxicity
studies (OECD 422). Developmental neurotoxicity studies and tests for
endocrine disruption.
Toxicokinetics
A full capability for Absorption Distribution Metabolism and Excretion (ADME)
studies.
Mutagenicity
Ames tests, in-vitro and in-vivo chromosome aberration
studies, in-vitro mouse lymphoma assay and in-vivo
micronucleus test.